Sequential Cellular Changes Produced by Types 5 and 7 Adenoviruses in Hela Cells and in Human Amniotic Cells

نویسندگان

  • Georgiana S. Boyer
  • Floyd W. Denny
  • Harold S. Ginsberg
چکیده

The sequential cytological changes which develop in tissue culture cells infected with adenovirus types 5 and 7 are described and compared with those produced by adenovirus types 1, 2, 3, and 4. The evidence that is presented indicates that types 1, 2, and 5 belong to one major subdivision of the adenovirus group and types 3, 4, and 7 to another. That the host cell nucleus is the principal site of adenovirus synthesis has been confirmed by fluorescent antibody studies. They have demonstrated the occurrence of type-specific adenovirus antigen in the characteristic intranuclear inclusions and other virus-induced structures reported to contain virus-like particles or shown by electronmicroscopy.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 110  شماره 

صفحات  -

تاریخ انتشار 1959